abstract：:Nitric oxide (*NO)-mediated toxicity has been involved in neurodegenerative diseases, including Parkinson's disease (PD). We have recently reported an increase of about 50% in *NO production rate in PMA-activated polymorphonuclear leukocytes (PMN) from either newly diagnosed or chronically treated PD patients. As humo...

journal_title：Journal of the neurological sciences

authors： Gatto EM,Riobó NA,Carreras MC,Schöpfer FJ,Pargament GA,Poderoso JJ

更新日期：1999-05-01 00:00:00

abstract：:Complex I is the largest of the mitochondrial respiratory chain proteins, and contains subunits encoded by both mitochondrial and nuclear genomes. Leber's hereditary optic neuropathy has been clearly linked to mutations of mitochondrial DNA complex I genes, and variable complex I functional defects have been reported....

journal_title：Journal of the neurological sciences

authors： Cock HR,Cooper JM,Schapira AH

更新日期：1999-05-01 00:00:00

abstract：:In previous work we demonstrated little effect of aging on the density and spatial pattern of epidermal innervation, however, this was restricted to two sites proximal and distal in the leg. To expand on these observations, we used punch skin biopsy in ten healthy controls to examine the variation in intra-epidermal n...

journal_title：Journal of the neurological sciences

authors： Lauria G,Holland N,Hauer P,Cornblath DR,Griffin JW,McArthur JC

更新日期：1999-04-01 00:00:00

abstract：:To compare muscle fiber loss in young and old mdx mice, we have blocked regeneration in one leg with a high dose (18 Gy) of X-rays administered at two ages; 16 days, just prior to the onset of the myopathy, and 15 weeks, when the myopathy is considered to be quiescent. Mice were examined 4 days after irradiation to lo...

journal_title：Journal of the neurological sciences

authors： Pagel CN,Partridge TA

更新日期：1999-04-01 00:00:00

abstract：:Neuropathy has been frequently reported in patients with IgG monoclonal gammopathy of undetermined significance (MGUS) but it is still unclear whether this association has clinical or pathogenetic relevance. In order to clarify the possible role of IgG MGUS in the neuropathy we correlated the clinical and electrophysi...

journal_title：Journal of the neurological sciences

authors： Di Troia A,Carpo M,Meucci N,Pellegrino C,Allaria S,Gemignani F,Marbini A,Mantegazza R,Sciolla R,Manfredini E,Scarlato G,Nobile-Orazio E

更新日期：1999-03-15 00:00:00

abstract：:A case of chorea-acanthocytosis (CA) syndrome is described. The presence of acanthocytes has usually been considered an important diagnostic marker of CA. However, it is not specific and other neurological diseases have to be considered. In the present report we rule out other diagnostic possibilities and show that th...

journal_title：Journal of the neurological sciences

authors： Sorrentino G,De Renzo A,Miniello S,Nori O,Bonavita V

更新日期：1999-03-01 00:00:00

abstract：:Systemic administration of opiates or direct injection of opioid peptides into the periaqueductal gray (PAG) produces a profound antinociception which is thought to be associated with inhibition of neuronal activity in the PAG. This inhibitory effect has been postulated to result from opiate inhibition of GABAergic ne...

journal_title：Journal of the neurological sciences

authors： Renno WM,Beitz AJ

更新日期：1999-03-01 00:00:00

abstract：:Proinflammatory cytokines contribute to the regulation of the disease process in inflammatory neuropathies. Cellular localisation of cytokine expression in CIDP nerve biopsies should provide further insight into the pathogenic mechanisms of the disease and the individual cells involved. In this study in situ hybridisa...

journal_title：Journal of the neurological sciences

authors： Mathey EK,Pollard JD,Armati PJ

更新日期：1999-02-01 00:00:00

abstract：:The aim of the present study was to determine whether a cognitive decline, related to multiple sclerosis (MS), also involves deficits in semantic memory. Semantic memory function was evaluated by studying the conscious understanding of conceptual meanings. A group of MS patients with cognitive decline was presented wi...

journal_title：Journal of the neurological sciences

authors： Laatu S,Hämäläinen P,Revonsuo A,Portin R,Ruutiainen J

更新日期：1999-01-15 00:00:00

abstract：:We report eight patients with adult-onset subacute sclerosing panencephalitis (SSPE), of which, four were treated with oral isoprinosine and four with intraventricular alpha-interferon plus oral isoprinosine. One of the four patients treated with oral isoprinosine died within two months, and the disease progressed in ...

journal_title：Journal of the neurological sciences

authors： Gokcil Z,Odabasi Z,Demirkaya S,Eroglu E,Vural O

更新日期：1999-01-01 00:00:00

abstract：:We study a patient with extrapontine myelinolysis (EPM), without central pontine myelinolysis (CPM), who exhibited changes in abnormalities observed with MRI. MRI in the acute stage of the bilateral basal ganglia showed a high signal intensity on T2-weighted images, and a low signal on T1-weighted images. The low sign...

journal_title：Journal of the neurological sciences

authors： Waragai M,Satoh T

更新日期：1998-12-11 00:00:00

abstract：:We studied a 21-year-old patient with clinical, biochemical and histochemical evidence of myophosphorylase deficiency and unusual repetitive episodes of pigmenturia. His muscle biopsy also revealed morphological signs of mitochondrial proliferation and a defect of complex I of the respiratory chain. His mother had exe...

journal_title：Journal of the neurological sciences

authors： Rubio JC,Martín MA,Bautista J,Campos Y,Segura D,Cabello A,Chinchón I,Arenas J

更新日期：1998-12-11 00:00:00

abstract：:In-situ hybridization with labeled oligonucleotide probes was applied to explore cytokine and chemokine mRNA expression in sections of striated muscle, the target organ in experimental autoimmune myasthenia gravis (EAMG), induced in Lewis rats by immunization with acetylcholine receptor (AChR) and complete Freund's ad...

journal_title：Journal of the neurological sciences

authors： Li H,Shi FD,Bai X,Huang Y,Diab A,He B,Link H

更新日期：1998-11-26 00:00:00

abstract：:Although fatigue is a frequent complaint of patients with multiple sclerosis (MS), little is known about the origins of multiple-sclerosis-associated fatigue. Our primary focus was to study if the extent of cerebral abnormalities, as shown on magnetic resonance imaging (MRI), had any relation with the frequency and in...

journal_title：Journal of the neurological sciences

authors： van der Werf SP,Jongen PJ,Lycklama à Nijeholt GJ,Barkhof F,Hommes OR,Bleijenberg G

更新日期：1998-10-08 00:00:00

abstract：:Nineteen patients with Motor Neurone Disease (MND) who had been living with their partners for at least two years prior to the onset of their illness, together with their partners, completed self-report questionnaires to investigate the impact of MND on both patients and carers. Physical disability and impact of the i...

journal_title：Journal of the neurological sciences

authors： Goldstein LH,Adamson M,Jeffrey L,Down K,Barby T,Wilson C,Leigh PN

更新日期：1998-10-01 00:00:00

abstract：:This study explores the severity of depression and anxiety experienced by patients suffering from motor neurone disease and seeks to link this to illness progression, recent life events and personality factors. The 18 patients who participated in the study were assessed for the presence of psychiatric symptoms using t...

journal_title：Journal of the neurological sciences

authors： Moore MJ,Moore PB,Shaw PJ

更新日期：1998-10-01 00:00:00

abstract：:To determine the prevalence and subtypes of dementia in southern Taiwan, a two-phase study consisting of a phase I screening survey using the Mini-Mental Status Examination (MMSE) and a phase II diagnostic examination using the CERAD neuropsychological battery and the neurobehavioral examination was conducted. Accordi...

journal_title：Journal of the neurological sciences

authors： Lin RT,Lai CL,Tai CT,Liu CK,Yen YY,Howng SL

更新日期：1998-09-18 00:00:00

abstract：:We assessed the incidence of hemorrhagic transformation and infarct volume after early intravenous infusion of recombinant human tissue plasminogen activator (rht-PA) in a newly developed rat cerebral embolic model. Male Wistar rats (n=60) were subjected to middle cerebral artery (MCA) occlusion by a single fibrin ric...

journal_title：Journal of the neurological sciences

authors： Zhang RL,Chopp M,Zhang ZG,Divine G

更新日期：1998-09-18 00:00:00

abstract：:Demonstration of the direct involvement of cranial blood vessels by varicella zoster virus (VZV) is facilitated by immunohistochemistry (IHC), in situ hybridization (ISH) and polymerase chain reaction (PCR) techniques. The extent to which an inflammatory vasculitis serves as the pathogenic mechanism for VZV encephalom...

journal_title：Journal of the neurological sciences

authors： Kleinschmidt-DeMasters BK,Mahalingam R,Shimek C,Marcoux HL,Wellish M,Tyler KL,Gilden DH

更新日期：1998-08-14 00:00:00

abstract：:We describe a patient with progressive aphemia with agrammatism that was later overlaid with buccofacial apraxia and pseudobulbar palsy. Pathological findings were consistent with those of classic Pick's disease with argyrophilic inclusions and neuronal achromasia, except for restricted cortical atrophy in the frontal...

journal_title：Journal of the neurological sciences

authors： Sakurai Y,Murayama S,Fukusako Y,Bando M,Iwata M,Inoue K

更新日期：1998-08-14 00:00:00

abstract：:Monthly dual-echo spin-echo (SE) and enhanced magnetic resonance imaging (MRI) after the injection of a standard dose (SD) of gadolinium (Gd) is the conventional approach to monitor short-term disease activity in multiple sclerosis (MS). In this study, the sensitivity of this approach in detecting active lesions in MS...

journal_title：Journal of the neurological sciences

authors： Filippi M,Mastronardo G,Bastianello S,Rocca MA,Rovaris M,Gasperini C,Pozzilli C,Comi G

更新日期：1998-07-15 00:00:00

abstract：:Cutaneous reflex (CR) was measured in 15 patients with acute lacunar stroke and in 15 age- and sex-matched normal subjects. EMG activities were recorded from the first dorsal interosseous muscle with surface electrodes, rectified and averaged. Intensity of the stimulation on the index finger was four times the sensory...

journal_title：Journal of the neurological sciences

authors： Chen CC,Chen JT,Wu ZA,Kao KP,Liao KK

更新日期：1998-07-15 00:00:00

abstract：:We report a Japanese family with adrenoleukodystrophy (ALD) with a three base pair deletion (delGAG 291) in the ALD gene. A variety of phenotypes were observed within this family. While the proband (patient 1) was classified as having a rare intermediate type of adult cerebral and cerebello-brain stem forms, his young...

journal_title：Journal of the neurological sciences

authors： Kano S,Watanabe M,Kanai M,Koike R,Onodera O,Tsuji S,Okamoto K,Shoji M

更新日期：1998-06-30 00:00:00

abstract：:Putative etiology was studied in 991 patients with symptomatic localization-related epilepsies seen in a university hospital in South India. They formed 39% of patients with various types of epilepsies and epileptic syndromes seen during the study period. Seizure occurred in close temporal association with an acute ce...

journal_title：Journal of the neurological sciences

authors： Murthy JM,Yangala R

更新日期：1998-06-11 00:00:00

abstract：:Hyperthermic isolated limb perfusion (HILP) with tumor necrosis factor alpha (TNFalpha) is effective for advanced melanoma and sarcoma of the limbs. Ten patients undergoing HILP with TNFalpha were evaluated by neurological examinations, nerve conduction studies (NCS), sympathetic skin responses (SSR) and conventional ...

journal_title：Journal of the neurological sciences

authors： Drory VE,Lev D,Groozman GB,Gutmann M,Klausner JM

更新日期：1998-06-11 00:00:00

abstract：:We assessed neuropsychological performances of 22 patients affected by Autosomal Dominant Cerebellar Ataxia type 1. All subjects completed a comprehensive battery of standardized tests requiring a verbal response, without time constraints. In order to verify the hypothesis that disease severity is the major factor in ...

journal_title：Journal of the neurological sciences

authors： Trojano L,Chiacchio L,Grossi D,Pisacreta AI,Calabrese O,Castaldo I,De Michele G,Filla A

更新日期：1998-05-07 00:00:00

abstract：:To evaluate the pathology of centenarian brains, which would reflect the ultimate stage of the aging process, 13 centenarians (M:F=1:12; mean+/-SD, 101.5+/-1.5 years) from the consecutive autopsy series were studied. None had severe dementia compatible with Alzheimer's disease (AD). As younger controls, 20 nondemented...

journal_title：Journal of the neurological sciences

authors： Itoh Y,Yamada M,Suematsu N,Matsushita M,Otomo E

更新日期：1998-04-15 00:00:00

abstract：:The brain constitutes an environment that is specifically designed to accommodate, regulate and shape immune responses. On one hand, the central nervous system (CNS) has traditionally been regarded as an immunologically privileged organ, owing to local tissue barrier and immunosuppressive microenvironment. On the othe...

journal_title：Journal of the neurological sciences

authors： Xiao BG,Link H

更新日期：1998-04-15 00:00:00

abstract：:Anti-beta 2-GPI antibodies (a beta 2-GPI) were found in serum from patients with anti-phospholipid syndrome (APS) and/or systemic lupus erythematosus (SLE). Since a beta 2-GPI are often found in patients with anti-cardiolipin antibodies (aCL), their role in thrombosis as well as other central nervous system (CNS) mani...

journal_title：Journal of the neurological sciences

authors： Caronti B,Pittoni V,Palladini G,Valesini G

更新日期：1998-04-01 00:00:00

abstract：:Machado-Joseph disease (MJD) is an autosomal dominantly inherited neurodegenerative disorder characterized by varying age of onset and pronounced phenotypic heterogeneity. The clinical core features include gait ataxia, external ophthalmoplegia, nystagmus, and bulging eyes. Recently, Kawagushi et al. (1994) cloned the...

journal_title：Journal of the neurological sciences

authors： Løkkegaard T,Nielsen JE,Hasholt L,Fenger K,Werdelin L,Tranebjaerg L,Lauritzen M,Colding-Jørgensen E,Grønbech-Jensen M,Henriksen OA,Sørensen SA

更新日期：1998-04-01 00:00:00

abstract：:A forty seven year old woman with previously undetected goitre, developed thyroid storm in the immediate postoperative period. Forty eight hours after undergoing nephrolithotomy for renal calculus, she was noted to have flaccid areflexic quadriparesis, most marked in the lower limbs. Electrophysiologic studies reveale...

journal_title：Journal of the neurological sciences

authors： Pandit L,Shankar SK,Gayathri N,Pandit A

更新日期：1998-03-05 00:00:00

abstract：:It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene...

journal_title：Journal of the neurological sciences

authors： Lalouschek W,Aull S,Korninger L,Mannhalter C,Pabinger-Fasching I,Schmid RW,Schnider P,Zeiler K

更新日期：1998-03-05 00:00:00

abstract：:Fast 60 degree head rotations of nine patients with cerebellar deficits were analysed and compared with those of nine normal subjects. The surface EMG activity from both Splenii capitis muscles were recorded. The triphasic pattern of reciprocal innervated neck muscles with regard to the duration, amplitude and onset o...

journal_title：Journal of the neurological sciences

authors： Dee J,Zangemeister WH

更新日期：1998-02-18 00:00:00

abstract：:Eclampsia accounts for a third of maternal mortality in developing countries. The neurological manifestations of eclampsia consist of seizures and alteration of sensorium or coma on a background of pre-eclampsia. Occasionally there can be focal neurological deficits too. Recent studies with CT scan and MRI have demons...

journal_title：Journal of the neurological sciences

authors： Thomas SV

更新日期：1998-02-18 00:00:00

abstract：:We assayed IL-6 in 105 cerebrospinal fluid (CSF) samples from patients with ALS, MS, HTLV-1 associated myelopathy (HAM), and controls. There was considerable overlap in IL-6 levels in all patient groups. The mean IL-6 in 27 patients with ALS was significantly higher than in 21 patients in the other neurological diseas...

journal_title：Journal of the neurological sciences

authors： Sekizawa T,Openshaw H,Ohbo K,Sugamura K,Itoyama Y,Niland JC

更新日期：1998-02-05 00:00:00

abstract：:Neurocysticercosis commonly presents with seizures, raised intracranial tension and dementia. The unusual location of the cysts may result in uncommon manifestations mimicking a host of neurological disorders. Ten patients with neurocysticercosis with rare clinical presentations have been described in this series. The...

journal_title：Journal of the neurological sciences

authors： Sawhney IM,Singh G,Lekhra OP,Mathuriya SN,Parihar PS,Prabhakar S

更新日期：1998-01-21 00:00:00

abstract：:The fibre composition of functionally different regions, the superficial and the deep portions, of the human masseter and the biceps brachii muscles of six elderly subjects (mean age 74 years) was studied by morphological and enzyme-histochemical methods. When compared to previous data for young adults, the masseter m...

journal_title：Journal of the neurological sciences

authors： Monemi M,Eriksson PO,Eriksson A,Thornell LE

更新日期：1998-01-21 00:00:00

abstract：:Quantitative sensory testing (QST) has been used clinically for the last two decades, yielding a substantial number of publications regarding these applications. In this review we tried to amass together the major findings of these publications into one monograph, excluding those dealing with pain. This was done with ...

journal_title：Journal of the neurological sciences

authors： Zaslansky R,Yarnitsky D

更新日期：1998-01-08 00:00:00

abstract：:Cerebral gliomas may cause a reduction of glucose metabolism in the cerebellum contralateral to the tumor side (crossed cerebellar diaschisis, CCD). We investigated whether CCD is related to tumor localization, histological grade, size and tumor biochemistry. Cerebellar glucose metabolism was measured in 44 glioma pat...

journal_title：Journal of the neurological sciences

authors： Otte A,Roelcke U,von Ammon K,Hausmann O,Maguire RP,Missimer J,Müller-Brand J,Radü EW,Leenders KL

更新日期：1998-01-01 00:00:00

abstract：:The sternocleidomastoid muscle is located in the neck and is both a neck rotator and flexor. Cervical dystonia, a focal dystonia disorder, is characterized by forceful involuntary contraction of a group of neck muscles, usually including the sternocleidomastoid. Little is known about the fiber type composition, fiber ...

journal_title：Journal of the neurological sciences

authors： McLoon LK

更新日期：1998-01-01 00:00:00